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Fluconazole (Diflucan)
Diflucan has largely replaced ketoconazole for systemic use due to a better safety profile.
Fluconazole (Diflucan)
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Fluconazole
Diflucan is used for chronic suppression in patients with recurrent mucosal infections.
Diflucan
Diflucan can increase phenytoin levels, risking toxicity.
Fluconazole
Its cost-effectiveness is a significant advantage over newer, broader-spectrum azoles.
Diflucan
Diflucan is available as a branded product and multiple generic equivalents.
Diflucan (Fluconazole)
Resistance to Diflucan is a growing concern, particularly with Candida glabrata and krusei.
Diflucan (Fluconazole)
Diflucan has reliable activity against Coccidioides immitis for certain non-meningeal cases.
Diflucan (Fluconazole)
May significantly increase cyclosporine and tacrolimus levels, requiring close monitoring.
Fluconazole (Diflucan)
Diflucan may be used for step-down therapy after initial echinocandin treatment for candidemia.
Fluconazole
Requires caution with other QTc-prolonging agents to avoid torsades de pointes.
Fluconazole (Diflucan)
Diflucan is a potent inhibitor of human CYP2C9 and CYP3A4, driving many drug interactions.
Fluconazole (Diflucan)
Diflucan’s efficacy can be reduced by concomitant use of rifampin.
Diflucan
Diflucan resistance can emerge during long-term suppressive therapy.
Diflucan (Fluconazole)
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Diflucan
Can be used in continuous renal replacement therapy; dosing depends on effluent rate.
Diflucan
Diflucan lacks meaningful activity against molds like Aspergillus, a critical limitation.
Fluconazole (Diflucan)
Diflucan is not a substrate of the P-glycoprotein efflux pump, aiding its distribution.
Fluconazole
Diflucan is not recommended for treatment of fungal endocarditis.
Diflucan
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Diflucan
QTc prolongation is a boxed warning for Diflucan, especially at high doses or with other agents.
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Diflucan
Diflucan’s efficacy can be reduced by concomitant use of rifampin.
Diflucan
Diflucan has a post-antimicrobial effect against some Candida species.
Fluconazole
Invasive candidiasis treatment duration is guided by resolution of symptoms and bloodstream clearance.
Diflucan
Activity against Coccidioides immitis makes it useful for certain non-meningeal forms of valley fever.
Diflucan
Diflucan is available as a branded product and multiple generic equivalents.
Fluconazole (Diflucan)
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Fluconazole
Diflucan may have in vitro synergy with flucytosine against some Candida species.
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Diflucan (Fluconazole)
Diflucan is on the WHO Model List of Essential Medicines.
Diflucan (Fluconazole)
Concomitant Diflucan and warfarin requires intense INR monitoring due to increased bleeding risk.
Fluconazole
Often compared to itraconazole, with a more predictable pharmacokinetic profile but narrower spectrum.
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Diflucan (Fluconazole)
Loading doses are used in serious infections to achieve steady-state concentrations rapidly.
Fluconazole (Diflucan)
Diflucan can cause a severe cutaneous reaction like Stevens-Johnson syndrome.
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Diflucan (Fluconazole)
Diflucan’s role has been defined by large, randomized controlled trials in HIV and ICU populations.
Charles Howell
The instructions on sampling frequency is actionable. We schedule periodic tests with micrometer calibration standards for indispensable points.