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Diflucan (Fluconazole)
Headache and gastrointestinal disturbances are the most frequently reported adverse events.
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Therapeutic drug monitoring is not routinely required but can be useful in specific scenarios.
Fluconazole
Diflucan is used in some protocols for antifungal lock therapy for catheter-related infections.
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Diflucan is often used in pediatric antifungal therapy with weight-based dosing.
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Multiple drug interactions stem from its inhibition of human CYP2C9 and CYP3A4.
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The development of Candida auris resistance has further limited its empirical utility.
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Invasive candidiasis treatment duration is guided by resolution of symptoms and bloodstream clearance.
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Diflucan is used in some selective digestive decontamination protocols.
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Diflucan is used for chronic suppression in patients with recurrent mucosal infections.
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Often used for treating urinary tract infections caused by susceptible Candida species.
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QTc interval prolongation is a rare but serious potential adverse effect.
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Diflucan lacks meaningful activity against molds like Aspergillus, a critical limitation.
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Diflucan can be considered for treatment of Malassezia folliculitis.
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Hydrochlorothiazide can increase fluconazole levels by reducing renal clearance.
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Headache and gastrointestinal disturbances are the most frequently reported adverse events.
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Significantly increases serum concentration of drugs like warfarin, phenytoin, and sulfonylureas.
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Serves as a model for the development of other triazole antifungal agents.
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The high oral bioavailability of Diflucan makes it exceptionally convenient for outpatient step-down therapy.
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Diflucan has reliable activity against Coccidioides immitis for certain non-meningeal cases.
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The long half-life (~30 hours) enables convenient once-daily dosing regimens.
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Diflucan is often used for esophageal candidiasis in immunocompromised hosts.
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Penetrates well into skin, nails, and blister fluid, supporting its use in dermatology.
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Hepatic metabolism becomes more significant in patients with end-stage renal disease.
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