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Diflucan
Diflucan is not active against the dimorphic fungus Blastomyces dermatitidis.
Diflucan
Diflucan is used in some selective digestive decontamination protocols.
Diflucan
Diflucan can increase phenytoin levels, risking toxicity.
Diflucan
Diflucan penetration into the CSF is excellent, a key pharmacological advantage.
Diflucan
Diflucan may have in vitro synergy with flucytosine against some Candida species.
Fluconazole
QTc prolongation is a boxed warning for Diflucan, especially at high doses or with other agents.
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Diflucan (Fluconazole)
Headache and gastrointestinal disturbances are the most frequently reported adverse events.
Fluconazole (Diflucan)
Therapeutic drug monitoring is not routinely required but can be useful in specific scenarios.
Fluconazole
Diflucan is used in some protocols for antifungal lock therapy for catheter-related infections.
Diflucan (Fluconazole)
Diflucan can be used for prolonged periods in certain endemic mycoses.
Fluconazole
Diflucan has activity against many dermatophytes, supporting its use in tinea infections.
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Diflucan
Hepatotoxicity, while rare, is a serious potential adverse effect of Diflucan.
Diflucan (Fluconazole)
The single-dose Diflucan regimen for vulvovaginal candidiasis revolutionized patient self-care.
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Fluconazole
Diflucan is often used in pediatric antifungal therapy with weight-based dosing.
Diflucan
Lacks reliable activity against Aspergillus species, a critical limitation in its spectrum.
Fluconazole
Can be used for certain cases of candidemia in stable patients with susceptible isolates.
Fluconazole (Diflucan)
Multiple drug interactions stem from its inhibition of human CYP2C9 and CYP3A4.
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Fluconazole
The development of Candida auris resistance has further limited its empirical utility.
Fluconazole
Not recommended for empirical treatment of serious infections in critically ill patients.
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Fluconazole
Activity is pH-dependent, with optimal efficacy in neutral to slightly acidic environments.
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Diflucan
Diflucan achieves good penetration into peritoneal fluid.
Diflucan
Invasive candidiasis treatment duration is guided by resolution of symptoms and bloodstream clearance.
Diflucan
A cornerstone of antifungal therapy in resource-limited settings due to cost and availability.
Diflucan (Fluconazole)
Diflucan is used in some selective digestive decontamination protocols.
Fluconazole (Diflucan)
Diflucan is used for chronic suppression in patients with recurrent mucosal infections.
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Fluconazole (Diflucan)
Often used for treating urinary tract infections caused by susceptible Candida species.
Fluconazole (Diflucan)
QTc interval prolongation is a rare but serious potential adverse effect.
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Fluconazole
Infusion-related reactions are rare, making rapid IV administration generally safe.
Diflucan
Teratogenicity concerns (Category D) limit its use in pregnancy, especially first trimester.
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Fluconazole
Diflucan lacks meaningful activity against molds like Aspergillus, a critical limitation.
Diflucan
Diflucan can be considered for treatment of Malassezia folliculitis.
Fluconazole (Diflucan)
Hydrochlorothiazide can increase fluconazole levels by reducing renal clearance.
Diflucan
Headache and gastrointestinal disturbances are the most frequently reported adverse events.
Diflucan
Significantly increases serum concentration of drugs like warfarin, phenytoin, and sulfonylureas.
Fluconazole (Diflucan)
Serves as a model for the development of other triazole antifungal agents.
Fluconazole
The high oral bioavailability of Diflucan makes it exceptionally convenient for outpatient step-down therapy.