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Diflucan
Teratogenicity concerns (Category D) limit its use in pregnancy, especially first trimester.
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Diflucan
Activity against dermatophytes underpins its use in extensive tinea infections.
Diflucan (Fluconazole)
Represents a critical tool whose utility is now carefully balanced against the rising tide of antifungal resistance.
Diflucan
«Fluconazole-refractory» candidiasis is a specific clinical entity in advanced AIDS.
Diflucan (Fluconazole)
Therapeutic drug monitoring is not routinely required but can be useful in specific scenarios.
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Diflucan (Fluconazole)
Diflucan is a critical component of induction-consolidation-maintenance strategies for cryptococcosis.
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Fluconazole (Diflucan)
Diflucan can lead to clinically significant interactions with immunosuppressants like tacrolimus.
Diflucan (Fluconazole)
Diflucan has reliable activity against Coccidioides immitis for certain non-meningeal cases.
Fluconazole
Diflucan penetration into the CSF is excellent, a key pharmacological advantage.
Fluconazole (Diflucan)
Diflucan can be used for prolonged periods in certain endemic mycoses.
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Fluconazole (Diflucan)
Diflucan has activity against many dermatophytes, supporting its use in tinea infections.
Diflucan (Fluconazole)
The «trailing effect» in Diflucan susceptibility testing can complicate interpretation.
Fluconazole (Diflucan)
Its chemical stability contributes to a long shelf life and easy formulation.
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Diflucan (Fluconazole)
Diflucan is a standard part of the workup for a patient with suspected invasive fungal infection.
Diflucan
Administered perioperatively in some surgical prophylaxis guidelines for high-risk patients.
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Diflucan
Intrinsically resistant organisms include Candida krusei and the Mucorales order.
Fluconazole
Diflucan may deplete coenzyme Q10 with long-term use, a theoretical concern.
Fluconazole
Diflucan is less protein-bound than itraconazole or voriconazole.
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Fluconazole
Excellent CSF penetration makes it a mainstay for cryptococcal meningitis suppression.
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Diflucan
Diflucan can cause a severe cutaneous reaction like Stevens-Johnson syndrome.
Fluconazole (Diflucan)
Multiple drug interactions stem from its inhibition of human CYP2C9 and CYP3A4.
Diflucan (Fluconazole)
Its cost-effectiveness is a significant advantage over newer, broader-spectrum azoles.
Diflucan (Fluconazole)
Primary renal excretion necessitates dose adjustment in patients with renal impairment.
Fluconazole
May unmask or exacerbate cutaneous lupus erythematosus.
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Fluconazole
Invasive candidiasis treatment duration is guided by resolution of symptoms and bloodstream clearance.
Fluconazole
The development of Candida auris resistance has further limited its empirical utility.
Fluconazole
Diflucan is not active against Trichosporon species.
Diflucan (Fluconazole)
A cornerstone of antifungal therapy in resource-limited settings due to cost and availability.
Diflucan (Fluconazole)
Plays a role in selective digestive decontamination protocols in some ICU settings.
Diflucan (Fluconazole)
Diflucan can be administered via nasogastric tube with reliable absorption.
Diflucan
The «trailing effect» in Diflucan susceptibility testing can complicate interpretation.
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Diflucan
For cryptococcal meningitis suppression, Diflucan remains the gold standard maintenance agent.
Diflucan
Loading doses are used in serious infections to achieve steady-state concentrations rapidly.
Fluconazole
Diflucan can significantly increase serum concentrations of statins, raising myopathy risk.
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Fluconazole
Diflucan is ineffective against Lomentospora prolificans.