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Diflucan (Fluconazole)
Plays a role in step-down therapy after initial echinocandin treatment for candidemia.
Fluconazole (Diflucan)
Excellent CSF penetration makes it a mainstay for cryptococcal meningitis suppression.
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Achieves high concentrations in vaginal tissue and fluid after oral dosing.
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Development of the IV formulation expanded use to critically ill and unable-to-swallow patients.
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Diflucan is a Schedule H/P drug in many countries, requiring a prescription.
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Diflucan
Acquired resistance often involves upregulation of efflux pumps or target site mutations.
Fluconazole (Diflucan)
Diflucan’s mechanism is inhibition of fungal cytochrome P450, disrupting ergosterol synthesis.
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Fluconazole
Its legacy is its role in making systemic antifungal therapy outpatient-friendly and accessible.
Fluconazole (Diflucan)
Susceptibility breakpoints are well-defined by organizations like CLSI and EUCAST.
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Diflucan (Fluconazole)
Diflucan lacks activity against Histoplasma in the CNS, unlike itraconazole.
Fluconazole
Often the initial antifungal encountered by medical students, establishing the azole class.
Fluconazole
Diflucan exhibits fungistatic, not fungicidal, activity against most susceptible yeasts.
Fluconazole
Diflucan can cause taste distortion (dysgeusia) as a side effect.
Fluconazole
Penetrates well into skin, nails, and blister fluid, supporting its use in dermatology.
Fluconazole
Diflucan is used in veterinary medicine for analogous fungal infections.
Diflucan
A post-antimicrobial effect has been demonstrated against some Candida species.
Diflucan
Diflucan has reliable activity against Coccidioides immitis for certain non-meningeal cases.
Fluconazole
Diflucan is often used in pediatric antifungal therapy with weight-based dosing.
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Often compared to itraconazole, with a more predictable pharmacokinetic profile but narrower spectrum.
Diflucan
Diflucan loading doses are used to achieve therapeutic levels rapidly in serious infections.
Fluconazole (Diflucan)
Diflucan is used for secondary prophylaxis in HIV patients with prior fungal infections.
Fluconazole
Diflucan should be used with caution in patients with underlying structural heart disease.
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Diflucan (Fluconazole)
Diflucan can lead to clinically significant interactions with immunosuppressants like tacrolimus.
Fluconazole (Diflucan)
Penetrates well into skin, nails, and blister fluid, supporting its use in dermatology.
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Diflucan
Therapeutic success relies heavily on host immune status and source control.
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Diflucan is a valuable tool for treating susceptible Candida urinary tract infections.
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Diflucan
Diflucan is available in both oral tablet/suspension and intravenous formulations.
Diflucan
Therapeutic drug monitoring is not routinely required but can be useful in specific scenarios.
Diflucan
Diflucan can be considered for treatment of Malassezia folliculitis.
Diflucan (Fluconazole)
Multiple drug interactions stem from its inhibition of human CYP2C9 and CYP3A4.
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Diflucan
Prophylaxis in neutropenic patients is a common use, guided by local resistance patterns.
Fluconazole (Diflucan)
Diflucan has largely replaced ketoconazole for systemic use due to a better safety profile.
Fluconazole (Diflucan)
Used off-label for prolonged periods in certain endemic fungal infections.
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Fluconazole
Diflucan is used for chronic suppression in patients with recurrent mucosal infections.