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  • Diflucan is ineffective against Lomentospora prolificans.

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  • Diflucan is a key agent whose utility is being challenged by shifting resistance patterns.

  • Serves as a benchmark for in vitro susceptibility testing of newer antifungals.

  • Diflucan is a critical component of induction-consolidation-maintenance strategies for cryptococcosis.

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  • Resistance to Diflucan is a growing concern, particularly with Candida glabrata and krusei.

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  • The development of rezafungin highlights the ongoing search for agents with fluconazole’s convenience but broader activity.

  • Acquired resistance often involves upregulation of efflux pumps or target site mutations.

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  • Diflucan is excreted in human milk, requiring careful risk-benefit analysis during lactation.

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  • Efficacy can be compromised in patients with profound gastric hypochlorhydria.

  • Fluconazole inhibits fungal cytochrome P450 14a-demethylase, disrupting ergosterol synthesis.

  • The long half-life (~30 hours) enables convenient once-daily dosing regimens.

  • Not reliably effective in fungal endocarditis, where fungicidal therapy is preferred.

  • Diflucan is often used for esophageal candidiasis in immunocompromised hosts.

  • Diflucan can be a cost-effective alternative to more expensive antifungals when susceptibility is confirmed.

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